Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis

Autor: Aleksandra Nikolić-Kokić, Nikola Tatalović, Jelena Brkljačić, Milica Mijović, Vojkan Nestorović, Ana Mijušković, Zorana Oreščanin-Dušić, Teodora Vidonja Uzelac, Milan Nikolić, Snežana Spasić, Duško Blagojević, Čedo Miljević
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13698
ISSN: 1422-0067
DOI: 10.3390/ijms232213698
Popis: Sexual dysfunction, as a noticeable adverse effect of atypical antipsychotic drugs (APDs) for the treatment of schizophrenia, has not been investigated in detail. A study was undertaken to investigate whether 28-day long treatment with clozapine, ziprasidone or sertindole (using a recommended daily dose for atypical antipsychotic therapy), induced histopathological changes both in rat testicles and prostate, changed the activity of the antioxidant defence system and altered blood testosterone and prolactin. Clozapine, ziprasidone and sertindole induced histopathological changes in rat testicular tissue, which could be attributed to a disturbed testicular antioxidant defence system in addition to an altered prolactin to testosterone ratio. None of the APD treatments induced histopathological changes in prostate. Our results demonstrate that APDs have the capacity to change both redox and endocrinological balance. One or both outcomes could underline testicular degeneration and disturbed spermatogenesis.
Databáze: OpenAIRE
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