ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy Inhibitor
| Autor: | Li‐Hong Wang, Ye Yuan, Jiao Wang, Ying Luo, Yang Lan, Jia Ge, Lei Li, Feng Liu, Qing Deng, Ze‐Xuan Yan, Mei Liang, Sen Wei, Xin‐Dong Liu, Yan Wang, Yi‐Fang Ping, Yu Shi, Shi‐Cang Yu, Xia Zhang, You‐Hong Cui, Xiao‐Hong Yao, Hua Feng, Tao Luo, Xiu‐Wu Bian |
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| Rok vydání: | 2022 |
| Předmět: |
General Chemical Engineering
General Engineering General Physics and Astronomy Medicine (miscellaneous) Autophagy-Related Proteins Membrane Proteins Glioma Biochemistry Genetics and Molecular Biology (miscellaneous) Phenotype Autophagy Basic Helix-Loop-Helix Transcription Factors Humans General Materials Science Biomarkers |
| Zdroj: | Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(27) |
| ISSN: | 2198-3844 |
| Popis: | Autophagy is a highly conserved process that is vital for tumor progression and treatment response. Although autophagy is proposed to maintain the stemness phenotype in adult diffuse glioma, the molecular basis of the link between autophagy and stemness is poorly understood, which makes it impossible to effectively screen for the population that will benefit from autophagy-targeted treatment. Here, ATG9B as essential for self-renewal capacity and tumor-propagation potential is identified. Notably, ASCL2 transcriptionally regulates the expression of ATG9B to maintain stemness properties. The ASCL2-ATG9B axis is an independent prognostic biomarker and indicator of autophagic activity. Furthermore, the highly effective blood-brain barrier (BBB)-permeable autophagy inhibitor ROC-325, which can significantly inhibit the progression of ASCL2-ATG9B axis |
| Databáze: | OpenAIRE |
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