Perioperative Duloxetine for Pain Management After Laparoscopic Hysterectomy: A Randomized Placebo-Controlled Trial
| Autor: | Emine Karabuk, Ozguc Takmaz, Savaş Gündoğan, Ercan Bastu, Muharrem Kocyigit, Esra Ozbasli, Suat Dede, Mete Güngör, Murat Naki, Faruk Köse |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Turkey Narcotic medicine.medical_treatment Analgesic Placebo-controlled study Duloxetine Hydrochloride Hysterectomy Placebo Drug Administration Schedule Perioperative Care Placebos Young Adult 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Double-Blind Method Surveys and Questionnaires Statistical significance medicine Humans Pain Management Duloxetine Aged Pain Measurement Analgesics Pain Postoperative 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Perioperative Length of Stay Middle Aged Pain management Analgesics Opioid chemistry 030220 oncology & carcinogenesis Anesthesia Female Laparoscopy business |
| Zdroj: | Journal of Minimally Invasive Gynecology. 27:665-672 |
| ISSN: | 1553-4650 |
| DOI: | 10.1016/j.jmig.2019.04.028 |
| Popis: | Study Objective To evaluate the effect of perioperative duloxetine on pain management in patients recovering from laparoscopic hysterectomy. Design A randomized placebo-controlled trial. Setting A university hospital. Patients Of 100 patients enrolled, 80 were randomized 1:1 to receive perioperative duloxetine (n = 40) or placebo (n = 40). Interventions Patients undergoing laparoscopic hysterectomy for benign conditions from November 2017 through March 2018 received 2 doses of 60 mg duloxetine or placebo 2 hours before and 24 hours after surgery. Measurements and Main Results The Quality of Recovery (QoR)-40 questionnaire was completed by participants after discharge. Study and control groups were compared in terms of questionnaire scores, opioid analgesic use, and hospital length of stay. The baseline characteristics of the groups were comparable; median total QoR-40 scores were 111 of 200 and 112 of 200 for duloxetine and the placebo group, respectively; the difference did not reach statistical significance (p = .91). Although the physical independence subcomponent of the recovery questionnaire was improved in favor of duloxetine, none of the subcomponents reached statistical difference between groups. The groups did not differ in terms of postoperative narcotic analgesic use and hospital length of stay (p >.05). Conclusion Perioperative duloxetine did not reduce pain, need for narcotic analgesia, or hospital length of stay following laparoscopic hysterectomy. |
| Databáze: | OpenAIRE |
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