For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time

Autor: L. Vervueren, Avigaelle Sher, Djamel Dabli, Pacôme Fosse, Francis Bouchet, Franck Lacoeuille, Aurélie Cahouet-Vannier, Olivier Couturier
Rok vydání: 2016
Předmět:
Zdroj: EJNMMI Research
ISSN: 2191-219X
DOI: 10.1186/s13550-016-0177-8
Popis: Background This study is an assessment of the impact of acquisition times on SUV with [18F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors. Methods One hundred six [18F]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUVmax (hottest voxel), SUVpeak (maximum average SUV within a 1-cm3 spherical volume), and SUVaverage were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [18F]FDG avid tumors (SUVmax ≥ 5), the SUVmax, SUVpeak, and SUV41% (isocontour threshold method) were computed. Results For tumors, SUVpeak values did not vary with acquisition time. SUVmax displayed significant differences between 1.5- and 5–10-min reconstruction times. SUV41% was the most time-dependent parameter. For the liver, the SUVaverage was the sole parameter that did not vary over time. Conclusions For [18F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUVpeak may be more robust than the SUVmax. The SUVaverage over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.
Databáze: OpenAIRE
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