Multiscale recordings reveal the dynamic spatial structure of human seizures
| Autor: | Edward M. Merricks, Guy M. McKhann, Catherine A. Schevon, Steven Tobochnik, Lisa M. Bateman, Tahra L. Eissa, Brian J A Gill, Andrew J. Trevelyan, R. Ryley Parrish, Ronald G. Emerson |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cellular activity Computer science Clinical settings Electroencephalography Seizure localization Article Surround inhibition lcsh:RC321-571 Focal seizures 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures medicine Humans Epilepsy surgery Human single unit activity Laboratory research lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neurons medicine.diagnostic_test Spatial structure Brain Data interpretation medicine.disease Electrodes Implanted 030104 developmental biology Neurology Microelectrodes Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Disease, Vol 127, Iss, Pp 303-311 (2019) Neurobiol Dis |
| ISSN: | 0969-9961 |
| Popis: | The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures. In this review, we describe results from human microelectrode studies, discuss some data interpretation pitfalls, and explain the current understanding of the key mechanisms of ictogenesis and seizure spread. |
| Databáze: | OpenAIRE |
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