Rosuvastatin pretreatment suppresses distant organ injury following unilateral renal ischemia-reperfusion in hypertensive Dahl salt-sensitive rats
| Autor: | Wan-Jun Zhu, Junichiro James Kazama, Yoshimitsu Hayashi, Makoto Kanno, Masaaki Nakayama |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Ischemia Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Kidney Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Rosuvastatin Rosuvastatin Calcium Rats Inbred Dahl biology business.industry Superoxide Dismutase Glomerulosclerosis General Medicine Organ Size Malondialdehyde medicine.disease Rats Elevated serum creatinine Endocrinology chemistry Nephrology Reperfusion Injury Hypertension biology.protein medicine.symptom Hydroxymethylglutaryl-CoA Reductase Inhibitors business Oxidative stress medicine.drug |
| Zdroj: | Nephrology (Carlton, Vic.). 23(11) |
| ISSN: | 1440-1797 |
| Popis: | Aim Ischemia-reperfusion (I/R) induces distant organ injury (DOI) via inflammation and oxidative stress. Statins have anti-inflammatory and anti-oxidant effects independent of their cholesterol-lowering properties. To clarify whether statins could suppress DOI, we investigated the effect of rosuvastatin (RO) on the contralateral kidney following unilateral renal I/R. Methods Dahl salt-sensitive rats (6-week-old) were randomly divided into four groups: sham, sham with RO, I/R, and I/R with RO. All rats were fed a high-salt (8%) diet for six weeks. RO (10 mg/kg/day) was pre-administered by supplementation to the drinking water for two weeks before I/R. The rats then underwent unilateral renal I/R (ischemia for 45 min). Three days after I/R, laboratory data, histological changes and protein expression levels of the contralateral kidney were assessed. Results I/R significantly elevated serum creatinine and malondialdehyde levels and induced a significantly higher glomerular sclerosis index and tubular dilation area of the contralateral kidney, with about 2-fold infiltration of ED-1-positive cells. In the I/R group, protein expression of superoxide dismutase (SOD) of the contralateral kidney was reduced to about 50% of the sham group. RO-pretreatment significantly suppressed all of these changes following I/R. Conclusion RO-pretreatment diminished contralateral kidney injury with the suppression of ED-1-positive cell infiltration and SOD reduction after I/R. RO appears to have a protective effect on DOI by its anti-inflammatory and anti-oxidant effects. |
| Databáze: | OpenAIRE |
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