Epimedium protects steroid‑induced avascular necrosis of femoral head in rats by inhibiting autophagy
| Autor: | Yunzong Huang, Chuangli Wang, Su Liu, Youjia Xu, Jianfei Ge, Shoujing Tian |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autophagy Cancer Research medicine.medical_specialty Osteoporosis epimedium Avascular necrosis 03 medical and health sciences Femoral head Immunology and Microbiology (miscellaneous) Internal medicine Medicine Gluteal muscles Bone mineral Epimedium biology business.industry Articles General Medicine medicine.disease biology.organism_classification 030104 developmental biology Endocrinology medicine.anatomical_structure Apoptosis steroid-induced avascular necrosis of femoral head bone mineral density business Glucocorticoid medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2018.6827 |
| Popis: | The effect of epimedium extracting solution on bone mineral density (BMD) of steroid-induced avascular necrosis of femoral head (SANFH) in rats was evaluated to further explore its function mechanism. Twenty-four Sprague-Dawley (SD) rats (male/female: 1/1) were randomly divided into three groups: the control (n=8), the glucocorticoid (n=8) and the epimedium (n=8) group. Rats in the glucocorticoid and the epimedium group were injected with prednisolone acetate injection in gluteal muscles with 15 mg/kg/day twice a week. The epimedium group was given 10 ml/kg ephedra extracting solution containing crude drug with the concentration of 1.5 g/ml daily by gavage. After 6 weeks, all the experimental rats were sacrificed and materials were extracted. The expression of autophagy-related proteins were detected by observing the bone of the femoral head. After comparison of the control group with the model group in BMD, it was found that there were significant differences (P0.05). Neither between the glucocorticoid and the epimedium group (P |
| Databáze: | OpenAIRE |
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