Long-term administration of pDC-Stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice
| Autor: | Kenta Jounai, Yoshihiko Sugihara, Konomi Ohshio, Tetsu Sugimura, Hiroaki Suzuki, Takayoshi Kirisako, Daisuke Fujiwara |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence Aging Interleukin-1beta Longevity Immunology Administration Oral Inflammation Biology medicine.disease_cause Andrology Mice 03 medical and health sciences chemistry.chemical_compound Immune system Oral administration medicine Animals Humans Immunology and Allergy Lung Skin Pharmacology Probiotics Lactococcus lactis Immunity Dendritic Cells biology.organism_classification Phenotype Mice Mutant Strains Lactic acid Paresis 030104 developmental biology Liver chemistry Virus Diseases Female medicine.symptom Carcinogenesis |
| Zdroj: | International Immunopharmacology. 58:166-172 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2018.03.024 |
| Popis: | The decline in immune function caused by aging increases the risk of infectious diseases, tumorigeneses and chronic inflammation, resulting in accelerating senescence. We previously reported a lactic acid bacteria, Lactococcus lactis strain Plasma (synonym of Lactococcus lactis subsp. lactis JCM 5805, Lc-Plasma), that stimulates plasmacytoid dendritic cells (pDCs), which play a crucial role in phylaxis from viral infection. In this study, we investigated the anti-aging effects of long-term oral administration of Lc-Plasma in a senescence-accelerated mouse strain, SAMP6. Mice given Lc-Plasma showed a significant improvement in survival rate at 82 weeks and a decreased senescence score as compared with control mice throughout this study. Anatomic analysis at 82 weeks revealed that the frequency of altered hepatocellular foci was significantly lower, and the incidence of other pathological findings in the liver and lungs tended to be lower in Lc-Plasma mice than in control mice. Transcription level of the IL-1β gene in lungs also tended to be lower in Lc-Plasma mice. Furthermore, the thinning of skin and age-related decrease in muscle mass were also significantly suppressed in the Lc-Plasma group as compared with the control group. Consistent with these phenotypic features, pDCs activity was significantly higher in Lc-Plasma mice than in control mice. In conclusion, long-term administration of Lc-Plasma can decelerate senescence and prolong lifespan via maintenance of the immune system due to activation of pDCs. |
| Databáze: | OpenAIRE |
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