Survivin expression in canine spontaneous cutaneous and subcutaneous tumors and its prognostic importance
| Autor: | Ranganath L, Suguna Rao, Kamaran A, Purushotham Km, S. M. Byregowda, Sathyanarayana Ml, Kishore Tk, Narayanaswamy Hd, Kavya N |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty 040301 veterinary sciences Veterinary medicine survivin Inhibitor of apoptosis SF1-1100 law.invention 0403 veterinary science 03 medical and health sciences 0302 clinical medicine quantitative real-time polymerase chain reaction law SF600-1100 Gene expression Survivin medicine Round cell prognostic value Polymerase chain reaction Survival analysis General Veterinary business.industry Mesenchymal stem cell 04 agricultural and veterinary sciences cutaneous and subcutaneous tumors Animal culture medicine.anatomical_structure 030220 oncology & carcinogenesis business Subcutaneous tissue Research Article |
| Zdroj: | Veterinary World Veterinary World, Vol 10, Iss 10, Pp 1286-1291 (2017) |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Aim: The present study was carried out to know the expression level of survivin, an inhibitor of apoptosis protein with an objective to determine its prognostic importance in cutaneous and subcutaneous tissue tumors of dogs. Materials and Methods: Forty cases of canine cutaneous and subcutaneous tissue tumors on histopathological examination revealed various round cell, epithelial, and mesenchymal cell tumors. Survivin gene expression was detected in all tumors tested by TaqMan real-time polymerase chain reaction assay by comparative cycle threshold method. Results: The mean survivin gene expression value of benign tumors was 0.94±0.63 folds and that of malignant tumors was 18.87±5.30 folds. Postsurgical follow up of 30 malignant tumor cases revealed death in 8, recurrence in 7, and neoplastic free alive status in 15 dogs with mean survivin fold difference values of 48.49±12.39, 14.63±6.37, and 5.034±2.27, respectively. The mean survivin gene expression value was significantly higher in malignant (30 cases, 18.87±5.30) compared to benign tumors (10 cases, 0.94±0.63), and it varied between various postsurgical follow-up groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|