Diagnostic advantage of stress computed tomography myocardial perfusion over single-photon emission computed tomography for the assessment of myocardial ischemia
| Autor: | Chihiro Suzuki, Daisuke Kashiwagi, Yasushi Ueki, Shumpei Sakurai, Shigeki Nishiyama, Atsushi Izawa, Kazuhiro Oguchi, Yoshikazu Yazaki, Uichi Ikeda, Shinichi Aso, Koichiro Kuwahara |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Ischemia Fractional flow reserve 030204 cardiovascular system & hematology Single-photon emission computed tomography Sensitivity and Specificity 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences Myocardial perfusion imaging 0302 clinical medicine medicine Humans Aged medicine.diagnostic_test business.industry Myocardial Perfusion Imaging Middle Aged medicine.disease Coronary arteries Fractional Flow Reserve Myocardial Stenosis medicine.anatomical_structure Female Radiology Cardiology and Cardiovascular Medicine Nuclear medicine business Tomography X-Ray Computed Perfusion Emission computed tomography |
| Zdroj: | Journal of cardiology. 70(2) |
| ISSN: | 1876-4738 |
| Popis: | Background This study compared adenosine stress computed tomography myocardial perfusion (CTP) with single-photon emission computed tomography (SPECT) in the diagnosis of functionally significant coronary artery stenosis using fractional flow reserve (FFR) as reference standard. Methods We included a total of 93 coronary arteries from 31 patients in whom at least one vessel with ≥50% stenosis was detected with computed tomography coronary angiography. All patients underwent both SPECT and adenosine stress CTP, followed by invasive coronary angiography (ICA) and FFR. Diagnostic accuracy between CTP and SPECT was compared according to positive findings of either ≥99% stenosis on ICA or FFR ≤0.8. Results Among 78 vessels eligible for the quantitative analyses, significant coronary artery disease (CAD) was diagnosed in 22 vessels of 19 patients. Comparison of CTP vs. SPECT for sensitivity, specificity, positive predictive value (PPV), negative predictive value, and accuracy in detecting significant CAD were 59% vs. 18%, 96% vs. 93%, 87% vs. 50%, 86% vs. 74%, and 86% vs. 72%, respectively. Conclusions CTP demonstrated a significant diagnostic advantage over SPECT in the identification of significant CAD, especially in terms of sensitivity and PPV. Adenosine stress CTP is useful for the noninvasive diagnosis of functionally significant CAD. |
| Databáze: | OpenAIRE |
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