Polymorphisms in dopaminergic genes predict proactive processes of response inhibition
| Autor: | Irina Baetu, Nicholas R. Burns, Nathan D. Beu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Neurotransmission Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Dopamine Dopamine receptor D2 Internal medicine Basal ganglia medicine Humans Allele 030304 developmental biology 0303 health sciences Receptors Dopamine D2 Mechanism (biology) business.industry Receptors Dopamine D1 General Neuroscience Dopaminergic Inhibition Psychological Endocrinology Proactive Inhibition Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Neuroscience. 49:1127-1148 |
| ISSN: | 1460-9568 0953-816X |
| DOI: | 10.1111/ejn.14323 |
| Popis: | The ability to inhibit a prepared emotional or motor action is difficult but critical to everyday functioning. It is well-established that response inhibition relies on the dopaminergic system in the basal ganglia. However, response inhibition is often measured imprecisely due to a process which slows our responses and increases subsequent inhibition success known as proactive inhibition. As the role of the dopamine system in proactive inhibition is unclear, we investigated the contribution of dopaminergic genes to proactive inhibition. We operationalised proactive inhibition as slower responses after failures to inhibit a response in a Go/No-Go paradigm and investigated its relationship to rs686/A at DRD1 (associated with increased gene expression) and rs1800497/T at DRD2 (associated with reduced D2 receptor availability). Even though our sample (N = 264) was relatively young (18-40 years), we found that proactive inhibition improves the ability to withhold erroneous responses in older participants (p = 0.002) and those with lower fluid intelligence scores (p |
| Databáze: | OpenAIRE |
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