Electrochemical Discrimination of Salbutamol from Its Excipients in VentolinTM at Nanoporous Gold Microdisc Arrays
| Autor: | Amelie Wahl, Vladimir Ogourstov, Ronan Mac Loughlin, Lorraine C. Nagle, Fiona Barry, Ian Seymour, James F. Rohan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Inhalable pharmaceutical Nanoconfinement effect Salbutamol Excipient electrochemical sensor Nanotechnology nanoporous gold Biosensing Techniques 02 engineering and technology TP1-1185 010402 general chemistry Electrochemistry 01 natural sciences Biochemistry Chloride Article Analytical Chemistry Excipients Nanopores Adsorption medicine inhalable pharmaceutical Humans Albuterol Electrical and Electronic Engineering Electrodes Instrumentation excipient Nanoporous Chemical technology Electrochemical Techniques 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics 0104 chemical sciences Electrochemical gas sensor selective discriminative amplification Electrochemical sensor salbutamol Electrode Linear sweep voltammetry Gold Nanoporous gold 0210 nano-technology nanoconfinement effect Selective discriminative amplification medicine.drug |
| Zdroj: | Sensors, Vol 21, Iss 3975, p 3975 (2021) Sensors (Basel, Switzerland) Sensors Volume 21 Issue 12 |
| ISSN: | 1424-8220 |
| Popis: | The emergence of specific drug–device combination products in the inhalable pharmaceutical industry demands more sophistication of device functionality in the form of an embedded sensing platform to increase patient safety and extend patent coverage. Controlling the nebuliser function at a miniaturised, integrated electrochemical sensing platform with rapid response time and supporting novel algorithms could deliver such a technology offering. Development of a nanoporous gold (NPG) electrochemical sensor capable of creating a unique fingerprint signal generated by inhalable pharmaceuticals provided the impetus for our study of the electrooxidation of salbutamol, which is the active bronchodilatory ingredient in VentolinTM formulations. It was demonstrated that, at NPG-modified microdisc electrode arrays, salbutamol is distinguishable from the chloride excipient present at 0.0154 M using linear sweep voltammetry and can be detected amperometrically. In contrast, bare gold microdisc electrode arrays cannot afford such discrimination, as the potential for salbutamol oxidation and chloride adsorption reactions overlap. The discriminative power of NPG originates from the nanoconfinement effect for chloride in the internal pores of NPG, which selectively enhances the electron transfer kinetics of this more sluggish reaction relative to that of the faster, diffusion-controlled salbutamol oxidation. Sensing was performed at a fully integrated three-electrode cell-on-chip using Pt as a quasi-reference electrode. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|