Past, present and future of HIV vaccine trials in developing countries
| Autor: | Claire Pattou-Markovic, Coumba Toure, Marie Louise Chang, Saladin Osmanov, José Esparza, Stephanie Nixon |
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| Rok vydání: | 2002 |
| Předmět: |
Developing country
HIV Infections Acquired immunodeficiency syndrome (AIDS) Environmental health parasitic diseases Humans Medicine HIV vaccine Sida Developing Countries AIDS Vaccines Clinical Trials as Topic General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Virology Clinical trial Infectious Diseases Clinical research Clinical Trials Phase III as Topic Lentivirus Molecular Medicine business Forecasting |
| Zdroj: | Vaccine. 20:1897-1898 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(02)00062-2 |
| Popis: | A safe, effective and accessible preventive vaccine is our best long-term hope for the control of the HIV/AIDS pandemic. The first phase I trial of an HIV vaccine was conducted in the US in 1987. Since then, >30 candidate vaccines have been tested in over 60 phase I/II clinical trials, involving >8000 healthy human volunteers. The majority of these trials have been conducted in the US and Europe, however, trials have also been conducted in developing countries (Brazil, China, Cuba, Haiti, Kenya, Thailand, and Uganda), including an ongoing phase III efficacy trial of a rgp120 candidate vaccine in Thailand. The effort to develop and evaluate HIV vaccines must increase, especially in Africa. |
| Databáze: | OpenAIRE |
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