Histological and Mechanical Behavior of INC 01 and 02 Bare Metal Stents Against a Commercial Stent: A Preclinical Study in a Porcine Model
| Autor: | Efraín Sánchez-Pérez, Minoru Arai-Ito Marco, Francisco J. Molina-Méndez, Gian Manuel Jiménez-Rodríguez, José Luis Romero-Ibarra, Félix Damas de los Santos, Eduardo A. Arias-Sánchez, Marco Antonio Peña-Duque, Sebastián Aceves-Díaz González, Arturo Abundes-Velasco, Marco Antonio Martínez-Ríos, Mauricio Sánchez-Jara, Erika Rodríguez-Barriga, Alberto Aranda-Fraustro, David A. Rodríguez-Parra |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bare-metal stent medicine.medical_specialty Swine medicine.medical_treatment Population Myocardial Ischemia 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Restenosis Intravascular ultrasound Coronary stent Medicine Animals Humans cardiovascular diseases education education.field_of_study medicine.diagnostic_test business.industry Stent General Medicine Middle Aged equipment and supplies medicine.disease surgical procedures operative 030104 developmental biology Treatment Outcome Metals 030220 oncology & carcinogenesis Conventional PCI Angiography Stents Radiology business |
| Zdroj: | Archives of medical research. 51(5) |
| ISSN: | 1873-5487 |
| Popis: | Background PCI is an expensive procedure in our population and it implies a huge cost for the institutions and National Health Service. Aim of the study The main objective was to evaluate the technical and biological success of two stents designed in Mexico. Methods Ten York pigs, 4–6 months of age, underwent implantation of the bare metal INC-01 (10 stents) and INC-02 (6 stents) coronary stent in addition to a conventional commercial stent (10 stents). Technical success was evaluated immediately with angiography and Intravascular Ultrasound IVUS, continued by a mean follow-up of 4 month and a final angiographic, IVUS and histological evaluation. Results Initial technical success, angiography and IVUS between the three stents were not significant. One stent presented restenosis in follow-up (commercial stent), but all other stents presented excellent clinical outcome, satisfactory angiographic and IVUS results. Inflammation, proliferation and endothelialization between the stents had no major differences in histological analysis in a mean of 4 months follow-up. Conclusions In this pig model, the INC 01 and INC 02 stents showed the same delivering technical success, angiographic and IVUS features, biological and histological response compared to commercial last generation stents. |
| Databáze: | OpenAIRE |
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