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Ziyang Wang,1,2 Meng Liu,1,2 Hao Lei,1,2 Panpan Lei,3 Xinyi Liu,1,2 Jing Zhang,1,2 Shengxiang Xiao,2 Yan Zheng,1,2 Yi-Guo Feng2 1Department of Dermatology, the First Affiliated Hospital of Xiâan Jiaotong University, Xiâan, Peopleâs Republic of China; 2Department of Dermatology, the Second Affiliated Hospital of Xiâan Jiaotong University, Xiâan, Peopleâs Republic of China; 3Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xiâan Jiaotong University School of Life Science and Technology, Xiâan, Peopleâs Republic of ChinaCorrespondence: Yi-Guo Feng, Department of Dermatology, the Second Affiliated Hospital of Xiâan Jiaotong University, School of Medicine, Xiâan, 730070, Peopleâs Republic of China, Email fengyiguo70@163.comBackground: Eruptive syringoma (ES) is a clinical variant of the appendageal tumor syringoma. Around 75% of ES arise in the head or neck, which makes them unsightly. ES is common in patients with amyloidosis, diabetes, and Downâs syndrome, suggesting that it may be associated with potential systemic effects. ES is a rare tumor with the unclear pathogenesis and no effective treatment.Methods: A PubMed search of ES was conducted. Plasma samples of patients with ES were acquired from the Department of Dermatology at Xiâan Jiaotong Universityâs Second Affiliated Hospital. After removing highly abundant proteins, plasma samples were subjected to proteomics and metabolomics analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS).Results: LC-MS/MS revealed 71 differentially expressed proteins and 18 differentially abundant metabolites. The functional analysis highlighted the importance of complement binding, coagulation, secretory granules and vesicle lumen. Further, the study revealed 15 hub genes associated with FGG, GC, APOE, FGA, FGB, C4A, C3, CRP, C4B, FLNA, TAGLN2, ANXA5, MYL6, MYL12B, and TLN1 organized into three clusters. The seed genes in each cluster were GC, FLNA, and MYL6. In addition, glycol metabolism was associated with variable abundance of serum metabolites, which explains the relatively high rate of ES among diabetics.Conclusion: This study suggests that immunological inflammation and tumor glycol metabolism may play significant role in the pathophysiology of ES.Keywords: eruptive syringomas, proteomics and metabolomics analysis, complement and coagulation cascades, glycol-metabolism |
