A Randomized, Controlled Trial of the Toxin-Blocking Effects of B Subunit in Family Members of Patients with Cholera
| Autor: | Jan Holmgren, K. M. Belayet Hossain, M. R. Khan, Roger I. Glass, William B. Greenough, M. Imdadul Huq |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Diarrhea
Male Cholera Toxin Protein subunit Enterotoxin Biology medicine.disease_cause Microbiology Enterotoxins Random Allocation Cholera medicine Humans Immunology and Allergy Clinical Trials as Topic Ganglioside Toxin Cholera toxin medicine.disease Small intestine Infectious Diseases medicine.anatomical_structure Vibrio cholerae Female Antitoxins |
| Zdroj: | Journal of Infectious Diseases. 149:495-500 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/149.4.495 |
| Popis: | A randomized, controlled field trial was performed to test the ability of B subunit, the nontoxic, binding portion of cholera toxin, to block the toxin receptors (Gmi ganglioside) in the small intestine and thereby prevent diarrhea in individuals infected with Vibrio cholerae 01. Of 1,922 family contacts of 370 index patients selected randomly to receive orally on two successive days either B subunit (low dose, 1.0 mg; high dose, 5.0 mg) or placebo, 190 were asymptomatically infected on day 1 or day 2 of the study and within 24 hr of receiving B subunit. During the first 24-hr period of follow-up, the relative risk of disease among contacts receiving B subunit versus placebo was 0.18 for the low dose (P = .08) and 0.50 for the high dose (P = .22). Subsequently the relative risk increased toward 1.0 and was at no single point significantly reduced, although in five of the six follow-up periods the risk of disease was less in the B subunit group. Vibrio cholerae 01 produces a pathogenic protein enterotoxin that consists of a toxic-active moiety (the A subunit) and a binding portion of five B subunits. In the human intestine the B subunits |
| Databáze: | OpenAIRE |
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