SARS-CoV-2 another kind of liver aggressor, how does it do that?

Autor: Daniel Arellanos-Soto, Sonia A Lozano-Sepulveda, Natalia Martinez-Acuña, Ana María Rivas-Estilla, Kame A Galán-Huerta
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral

GI
Gastrointestinal

ACE2
Specialties of internal medicine
Article
Virus
MAFLD
Metabolic-associated fatty liver disease

Betacoronavirus
03 medical and health sciences
Liver disease
0302 clinical medicine
ORF
Open Reading Frame

ACE2
Angiotensin-converting enzyme 2

Pandemic
GGT
Gamma glutamyl transpeptidase

medicine
Humans
In patient
Pandemics
ALT
Alanine transaminase

COVID-19
Coronavirus infectious disease 2019

Respiratory distress
Hepatology
business.industry
SARS-CoV-2
Liver Diseases
GTEx
Genotype-Tissue Expression

COVID-19
General Medicine
medicine.disease
AIH
Autoimmune Hepatitis

respiratory tract diseases
nsp
Nonstructural proteins

Pneumonia
Liver
RC581-951
A-aDO2
Alveolar-arterial Oxygen Gradient

030220 oncology & carcinogenesis
Liver impairment
Immunology
030211 gastroenterology & hepatology
Liver dysfunction
Coronavirus Infections
AST
Aspartate aminotransferase

business
Zdroj: Annals of Hepatology, Vol 19, Iss 6, Pp 592-596 (2020)
Annals of Hepatology
ISSN: 1665-2681
Popis: Clinical manifestations of SARS-CoV-2 infection include more frequently fever and cough, but complications (such as pneumonia, respiratory distress syndrome, and multiorgan failure) can occur in persons with additional comorbidities. Liver dysfunction is one of the most striking affections among patients suggesting that SARS-CoV-2 may represent a new king of liver aggressor. However, the molecular process underlying this phenomenon is still unclear. In this work, we overview the most recent findings between the molecular biology of the virus, pathogenic mechanisms, and its relationship to liver disease observed in patients.
Databáze: OpenAIRE