Cowpox Virus Inhibits the Transporter Associated with Antigen Processing to Evade T Cell Recognition
| Autor: | Dina Alzhanova, Klaus Früh, Isabel Scholz, Erika Hammarlund, Mary J. Wagner, Daniëlle Horst, David M. Edwards, Mark K. Slifka, Emmanuel J. H. J. Wiertz, Chris Upton |
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| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
MICROBIO viruses Cowpox Antigen presentation Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology(all) Virology MHC class I medicine MOLIMMUNO Molecular Biology 030304 developmental biology 0303 health sciences biology Cowpox virus Transporter associated with antigen processing MHC restriction medicine.disease 3. Good health chemistry biology.protein CELLBIO Parasitology Vaccinia CD8 030215 immunology |
| Zdroj: | Cell Host & Microbe. 6:433-445 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2009.09.013 |
| Popis: | Summary Cowpox virus encodes an extensive array of putative immunomodulatory proteins, likely contributing to its wide host range, which includes zoonotic infections in humans. Unlike Vaccinia virus, cowpox virus prevents stimulation of CD8 + T cells, a block that correlated with retention of MHC class I in the endoplasmic reticulum by the cowpox virus protein CPXV203. However, deletion of CPXV203 did not restore MHC class I transport or T cell stimulation. Here, we demonstrate the contribution of an additional viral protein, CPXV12, which interferes with MHC class I/peptide complex formation by inhibiting peptide translocation by the transporter associated with antigen processing (TAP). Importantly, human and mouse MHC class I transport and T cell stimulation was restored upon deletion of both CPXV12 and CPXV203 , suggesting that these unrelated proteins independently mediate T cell evasion in multiple hosts. CPXV12 is a truncated version of a putative NK cell ligand, indicating that poxviral gene fragments can encode new, unexpected functions. |
| Databáze: | OpenAIRE |
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