The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring: a systematic review and meta-analysis

Autor: R. Polson, H. C. van Woerden, C. Jayasinghe, Philip Wilson
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Pediatrics
Intelligence
Neurodevelopment
Child Behavior
Folic Acid/administration & dosage
Review
law.invention
0302 clinical medicine
Child Development
Cognition
Randomized controlled trial
Pregnancy Complications
Hematologic/epidemiology
law
Pregnancy
Prevalence
030212 general & internal medicine
Child
Prenatal Care/methods
Anemia
Iron-Deficiency
Research Support
Non-U.S. Gov't
lcsh:RJ1-570
Prenatal Care
Anemia
Iron-Deficiency/epidemiology
Minimal effect
Meta-analysis
Female
Research Article
medicine.medical_specialty
Offspring
Prenatal care
03 medical and health sciences
Folic Acid
Iron deficiency anaemia
030225 pediatrics
medicine
Journal Article
Humans
Antenatal
Iron supplementation
business.industry
Pregnancy Complications
Hematologic
lcsh:Pediatrics
medicine.disease
Child development
Pediatrics
Perinatology and Child Health
Dietary Supplements
business
Meta-Analysis
Zdroj: BMC Pediatrics, Vol 18, Iss 1, Pp 1-9 (2018)
Jayasinghe, C, Polson, R, van Woerden, H C & Wilson, P 2018, ' The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring : a systematic review and meta-analysis ', BMC Pediatrics, vol. 18, no. 1, 150 . https://doi.org/10.1186/s12887-018-1118-7
BMC Pediatrics
ISSN: 1471-2431
DOI: 10.1186/s12887-018-1118-7
Popis: Background Although antenatal iron supplementation is beneficial to mothers, its impact on the neurodevelopment of offspring is controversial. A systematic review and meta-analysis was undertaken to assess whether routine maternal antenatal iron supplementation confers later neurodevelopmental benefit to offspring. Methods Electronic databases were searched using MESH terms or key words and identified papers were reviewed by two independent reviewers. The study quality was assessed using the Cochrane risk of bias assessment tool. The review was registered in the PROSPERO CRD data base. Results Seven publications were identified, based on four randomised trials published between 2006 and 2016. Three of the trials were in the Asian sub-continent. A range of tools were used to evaluate neurodevelopment. Meta-analysis of outcomes from the three RCTs meeting our inclusion criteria showed minimal effect of antenatal iron supplementation on the neurodevelopment of offspring, which was not statistically significant: weighted mean difference of 0.54 (95% CI: -0.67 to 1.75); test for overall effect Z = 0.87; p = 0.38; and heterogeneity 48%. Meta-analysis of outcomes of these RCTs at later stages of development produced similar results. Conclusions The benefit of routine antenatal iron supplementation on neurodevelopment in offspring was not statistically significant in this relatively limited set of trials, and some benefit cannot be excluded in areas with a high prevalence of maternal anaemia. A large randomized controlled trial showing significant benefit would be required to modify our conclusions. Electronic supplementary material The online version of this article (10.1186/s12887-018-1118-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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