Dehydroepiandrosterone Antagonizes the Suppressive Effects of Dexamethasone on Lymphocyte Proliferation*
| Autor: | Edward W. Bernton, Keith L. Blauer, Merrily Poth, William M. Rogers |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
endocrine system
medicine.medical_specialty Lymphocyte Dehydroepiandrosterone Spleen Thymus Gland Lymphocyte proliferation Biology Lymphocyte Activation Dexamethasone Mice Endocrinology In vivo Internal medicine polycyclic compounds medicine Splenocyte Animals Lymphocytes Mice Inbred C3H Organ Size medicine.anatomical_structure Mitogens hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Endocrinology. 129:3174-3179 |
| ISSN: | 1945-7170 0013-7227 |
| Popis: | Administration of dehydroepiandrosterone (DHEA) appears to have physiological effects opposing those of glucocorticoids in several animal models. Recently, immunomodulatory effects of treatment with DHEA have been described. This paper reports the effects of DHEA treatment on splenocyte blastogenic responses as well as thymic and spleen weights in C3H/HeN mice. Pretreatment of mice with sc DHEA (60 mg/kg.day) for 3 days in vivo antagonized the profound suppression of in vitro blastogenic responses seen in T- and B-lymphocytes after a single injection of dexamethasone (DEX; 60 mg/kg). Pretreatment with DHEA also significantly reduced dexamethasone-induced thymic and splenic atrophy. Splenic lymphocytes from DHEA-treated mice were markedly more resistant to in in vitro suppression of blastogenesis by DEX at 10(-6)-10(-8) M compared to lymphocytes from control mice. However, DHEA added to lymphocyte cultures in vitro over a concentration range from 10(-7)-10(-8) M failed to protect against suppression of mitogenic responses caused by addition of DEX to cultures. In summary, DHEA given in vivo antagonizes the suppressive actions of DEX on lymphoid target tissues in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|