Easy access to constrained peptidomimetics and 2,2-disubstituted azetidines by the unexpected reactivity profile of α-lithiated N-Boc-azetidines

Autor:	Emanuela Capitanelli, Guy J. Clarkson, Leonardo Degennaro, Renzo Luisi, Giovanna Parisi, Antonella Pierro, Giuseppe Romanazzi
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Materials Chemistry2506 Metals and Alloys Peptidomimetic Stereochemistry Azetidine Stereoisomerism Ring (chemistry) Catalysis Coatings and Films chemistry.chemical_compound Materials Chemistry Electronic Molecule Reactivity (chemistry) Chemistry (all) Ceramics and Composites Electronic Optical and Magnetic Materials Surfaces Coatings and Films 2506 Optical and Magnetic Materials Molecular Structure Chemistry Metals and Alloys Regioselectivity General Chemistry Surfaces Azetidines Peptidomimetics
Popis:	The reactivity profile of lithiated N-Boc-2-arylazetidines has been investigated filling a gap in the chemistry of this class of four-membered heterocycles. Two unexpected and unprecedented results have been observed: an "ortho-effect" accounting for the regioselective functionalization of the azetidine ring, and self-condensation leading to new and interesting azetidine-based peptidomimetics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5ff31e4f571edc66a08b78a6393f8f http://hdl.handle.net/11589/55914 Zobrazit plný text záznamu