Cardiac Resynchronization Therapy: A Pilot Study Examining Cognitive Change in Patients Before and After Treatment
| Autor: | Samuel F. Sears, Jamie B. Conti, Emily A. Kuhl, Natalie J. Cross, Duane E. Dede, Neha K. Dixit, Adrienne H. Kovacs, Eva R. Serber, Lauren D. Vazquez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Time Factors medicine.medical_treatment Cardiac resynchronization therapy Clinical Investigations Electric Countershock Pilot Projects Neuropsychological Tests Executive Function Ventricular Dysfunction Left Cognition Quality of life Internal medicine Surveys and Questionnaires medicine Memory span Humans Attention Prospective Studies Cardiac Output Prospective cohort study Aged Heart Failure business.industry Cardiac Pacing Artificial General Medicine Middle Aged medicine.disease Defibrillators Implantable Treatment Outcome Heart failure Cerebrovascular Circulation Physical therapy Cardiology Quality of Life Female Cardiology and Cardiovascular Medicine business Cognition Disorders Neurocognitive Psychosocial |
| Popis: | Background Cardiovascular patients with reduced cardiovascular output and capacity such as those with congestive heart failure (CHF) have demonstrated cognitive-related dysfunction. The use of cardiac resynchronization therapy (CRT) is considered standard care for CHF patients who do not improve despite optimal medical therapy. Cardiac resynchronization therapy may improve neurocognitive and psychosocial functioning in patients by increasing cardiac output and cerebral perfusion. Methods A total of 20 patients were examined before and 3 months after CRT device implantation, via administration of standard neurocognitive and psychosocial testing measures. Results Significant improvements in neurocognitive measures of attention (Digit Span: t[20] = − 2.695 [55.94±9.27–62.31±10.05], P = 0.015) and information processing (Digit Symbol: t[20] = − 4.577, P < 0.001; Controlled Oral Word Association Test: t[20] = − 3.338, P = 0.004) were demonstrated. Improvements in cardiac-specific quality of life were also significant (Minnesota Living with Heart Failure Questionnaire: t[16] = 3.544, P = 0.005 [55.17±18.23–36.75±18.00]; The Left Ventricular Dysfunction Questionnaire: t[16] = 3.544, P = 0.003 [63.43±23.35–43.29±21.62]). Conclusion These results represent clinically significant, qualitative, and quantitative cognitive functional benefits for patients from a neurocognitive and psychosocial perspective. Results suggest that biventricular pacing improves cardiovascular outcome and psychosocial functioning in patients with CHF. The future investigation of a larger sample would be beneficial in establishing the depth and breadth of this improvement. Copyright © 2010 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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