Role of Rab GTPases in HSV-1 infection: Molecular understanding of viral maturation and egress
| Autor: | Sohail Raza, Muhammad Asad Ali, Urooj Husain, Masood Rabbani, Gualtiero Alvisi, Muhammad Nawaz, Aftab Ahmad Anjum, Ali Ahmad Sheikh, Tahir Yaqub, Farzana Shahin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
viruses Viral maturation GTPase Herpesvirus 1 Human Virus Physiological Phenomena Biology Microbiology rab27 GTP-Binding Proteins 03 medical and health sciences Viral Proteins 0302 clinical medicine Viral envelope Viral Envelope Proteins Humans Virus Release Egress Herpesvirus 1 Rab GTPases Vesicular transport Glycoproteins rab5 GTP-Binding Proteins Virus Assembly DNA virus Herpes Simplex Cell biology Transport protein Vesicular transport protein rab1 GTP-Binding Proteins Protein Transport 030104 developmental biology Infectious Diseases rab GTP-Binding Proteins Rab 030217 neurology & neurosurgery |
| Zdroj: | Microbial pathogenesis. 118 |
| ISSN: | 1096-1208 |
| Popis: | Most enveloped viruses exploit complex cellular pathways for assembly and egress from the host cell, and the large DNA virus Herpes simplex virus 1 (HSV-1) makes no exception, hijacking several cellular transport pathways for its glycoprotein trafficking and maturation, as well as for viral morphogenesis and egress according to the envelopment, de-envelopment and re-envelopment model. Importantly Rab GTPases, widely distributed master regulators of intracellular membrane trafficking pathways, have recently being tightly implicated in such process. Indeed, siRNA-mediated genetic ablation of specific Rab proteins differently affected HSV-1 production, suggesting a complex role of different Rab proteins in HSV-1 life cycle. In this review, we discuss how different Rabs can regulate HSV-1 assembly/egress and the potential therapeutic applications of such findings for the management of HSV-1 infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect