Cellular calcium signaling in the aging brain
| Autor: | Mantosh Kumar, Remya Chandran, Sethu Lakshmi, R.V. Omkumar, Lakshmi Kesavan, Chittalakkottu Sadasivan, Reena Sarah Jacob, Sowmya Gunasekaran |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Neurons
0301 basic medicine Aging Voltage-dependent calcium channel Excitotoxicity Brain Biology medicine.disease_cause Cell biology Cell calcium 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine medicine Animals Humans Aging brain Calcium Signaling Neuroscience 030217 neurology & neurosurgery Oxidative stress Calcium signaling |
| Zdroj: | Journal of Chemical Neuroanatomy. 95:95-114 |
| ISSN: | 0891-0618 |
| Popis: | Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death. Calcium signaling proteins are pursued as promising drug targets for many aging related diseases. This review attempts to summarize changes in calcium signaling in the brain as a result of aging. |
| Databáze: | OpenAIRE |
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