CCR5 -Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes
| Autor: | Bartosz Słomiński, Jolanta Myśliwska, Urszula Ławrynowicz, Agnieszka Brandt, Maria Skrzypkowska, Monika Ryba-Stanisławowska |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Adolescent Receptors CCR5 Disease Ligands Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Gene Frequency Humans Medicine Genetic Predisposition to Disease Allele Molecular Biology Alleles Genetic Association Studies Type 1 diabetes Diabetic Retinopathy Polymorphism Genetic business.industry Cell adhesion molecule Diabetic retinopathy medicine.disease Diabetes Mellitus Type 1 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Immunology Female Gene polymorphism Inflammation Mediators business Complication Cell Adhesion Molecules Biomarkers Retinopathy |
| Zdroj: | Molecular and Cellular Endocrinology. 439:256-260 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2016.09.009 |
| Popis: | Aim The aim of the study was to assess the relationship between the CCR5-Δ32 polymorphism and the risk of diabetic retinopathy (DR) in patients with DM1. Methods We examined 420 patients and 350 healthy controls. The analysis concerned CCR5-Δ32 polymorphism as well as levels of serum inflammatory markers (CRP, TNF-α), adhesion molecules (VCAM, ICAM-1, ICAM-3) and CCR5 ligand (MCP-1). Results We found a negative association between DM1 and Δ32 allele. Moreover, the frequency of Δ32 allele was higher in a group with DR in comparison to control subjects without this complication. We also found that Δ32 carriers had the highest levels of: HbA1c, inflammatory markers, adhesion molecules and CCR5 ligand. Conclusions The findings of our studies suggest that the CCR5-Δ32 polymorphism is associated with DM1 such that the Δ32 allele protects against the development of DM1 and increases the risk of DR in patients who have already developed the disease. |
| Databáze: | OpenAIRE |
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