Tau protein as a serum marker of brain damage in mild traumatic brain injury: Preliminary results

Autor: Seref Dogan, Yesim Ozarda Ilcol, Naile Bolca, Halil Özgüç, Mufit Parlak, Mehtap Bulut, Ender Korfali, Özlem Köksal
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahisi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı., Uludağ Üniversitesi/Genel Cerrahi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Bulut, M., Köksal, Özlem, Doğan, S., Bolca, N., Özgüç, H., Korfalı, E. E, İlçol, Yeşim Özarda, Parlak, M., AAK-8332-2020
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Traumatic brain injury
Tau protein
Research & experimental medicine
tau Proteins
Csf
Brain damage
Neuronal damage
Gastroenterology
Serum tau protein
Cerebrospinal fluid
Minor head-injury
Internal medicine
medicine
Health Status Indicators
Humans
Glasgow Coma Scale
Pharmacology (medical)
Prospective Studies
Mild traumatic brain injury
Medicine
research & experimental
Prospective cohort study
Aged
Cranial CT
biology
Pharmacology & pharmacy
High risk
business.industry
General Medicine
Middle Aged
Ubiquitin Thiolesterase
Phosphopyruvate Hydratase
Glial Fibrillary Acidic Protein
medicine.disease
Rheumatology
Cerebrospinal-fluid
Computed-tomography
Brain Injuries
Anesthesia
Serial s-100
biology.protein
Biomarker (medicine)
Female
medicine.symptom
Tomography
X-Ray Computed
business
Biomarkers
Zdroj: Advances in Therapy. 23:12-22
ISSN: 1865-8652
0741-238X
DOI: 10.1007/bf02850342
Popis: The objective of this study was to investigate the diagnostic value of serum tau protein in determining the severity of traumatic brain injury in patients with mild traumatic brain injury (mTBI) and high-risk patients. Adult patients who presented to our emergency department (ED) with mTBI over 1 year were prospectively enrolled. Patients underwent cranial computed tomography (CT) and were subdivided into high- and low-risk groups, according to the probability of resultant intracranial injury. Serum tau levels of 60 patients and 20 healthy volunteers, who served as a control group, were measured. The mean age of the 60 patients (45 males, 15 females) was 32.5 years (range, 15-66 y). Mean Glasgow Coma Scale (GCS) score was 14+/-0.6. CT scans demonstrated intracranial injury in 11 patients (18.3%) and depressed fracture in 4 patients (6.7%). Serum tau levels of patients (188+/-210 pg/mL), compared with those of controls (86+/-48 pg/mL), were relatively higher; however, differences were not statistically significant (P=.445). Also, serum tau levels of high-risk patients (307+/-246 pg/mL) were significantly higher than those of low-risk patients (77+/-61 pg/mL) (P=.001). A total of 48 patients (80%) were accessible for follow-up after 6 months. Postconcussive syndrome was observed in 8 patients, 5 of whom had serum tau protein levels that were higher than those of the other 3 patients. However, no statistically significant difference was observed (P.05). Investigators of the present study noted that serum tau levels in patients with mTBI were increased. Therefore, it is believed that this biomarker may prove helpful in identifying high-risk patients with mTBI. However, additional studies are needed to establish the diagnostic value of serum tau in detecting traumatic brain injury in patients with mTBI.
Databáze: OpenAIRE
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