Mild Parkinsonian Signs in a Community Ambulant Population

Autor: Eng-King Tan, Yin Xia Chao, Zheyu Xu, Usanee Chotphoksap, Samuel Yong-Ern Ng, Linda L H Lim, Shu-Ting Chua, Yin Minn Aye, Adeline S Y Ng, Ming-Ching Wen, Gerald M. Liew, Louis C.S. Tan
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Multivariate analysis
Parkinson's disease
Population
Prodromal Symptoms
Disease
REM Sleep Behavior Disorder
REM sleep behavior disorder
Severity of Illness Index
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Rating scale
Risk Factors
Internal medicine
medicine
Prevalence
Humans
Cognitive Dysfunction
skin and connective tissue diseases
education
Aged
education.field_of_study
business.industry
Age Factors
nutritional and metabolic diseases
Montreal Cognitive Assessment
Cognition
Parkinson Disease
Middle Aged
medicine.disease
030104 developmental biology
Cross-Sectional Studies
Female
Neurology (clinical)
Independent Living
business
030217 neurology & neurosurgery
Zdroj: Journal of Parkinson's disease. 10(3)
ISSN: 1877-718X
Popis: BACKGROUND Mild parkinsonian signs (MPS) are common in the older adult and associated with a wide range of adverse health outcomes. There is limited data on the prevalence of MPS and its significance. OBJECTIVE To determine the prevalence of MPS in the community ambulant population and to evaluate the relationship of MPS with prodromal features of Parkinson's disease (PD) and cognition. METHODS This cross-sectional community-based study involved participants aged ≥50 years. Parkinsonian signs were assessed using the modified Unified Parkinson's Disease Rating Scale (mUPDRS) and cognition using the Montreal Cognitive Assessment (MoCA). Premotor symptoms of PD were screened using a self-reported questionnaire. Linear regression was used to assess the association of MPS with premotor symptoms of PD and cognitive impairment. RESULTS Of 392 eligible participants, MPS was present in 105 (26.8%). Mean age of participants with MPS was 68.8±6.9 years and without MPS was 66.1±5.9 years (p
Databáze: OpenAIRE
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