The metabolic fate ofN‐isopropyl‐N‐phenyloxamic acid in the rat and the milk goat
| Autor: | C. E. Price, J. E. Bakke |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Time Factors Urinary system Metabolite Urine Biology Milking chemistry.chemical_compound Species Specificity Internal medicine medicine Animals Tissue Distribution Amino Acids Propachlor Biotransformation Feces Oxamic Acid Chromatography Goats General Medicine Metabolism Pollution Rats N-isopropyl-N-phenyloxamic acid Endocrinology chemistry Female Food Science |
| Zdroj: | Journal of Environmental Science and Health, Part B. 14:279-290 |
| ISSN: | 1532-4109 0360-1234 |
| Popis: | Rats excreted the 14C from a single oral dose of N‐isopropyl‐N‐[14C]phenyloxamic acid [I, a soil metabolite from 2‐chloro‐N‐isopropylacetanilide (propachlor)] in approximately equal quantities in the urine (49.2%) and feces (48.2%). A milking goat given daily oral doses of [ 14C]‐I (1 mg of I three times daily) excreted more 14C in the feces (53.6%) than it excreted in the urine. From both species, I accounted for 97 to 100% of the urinary 14C, and all of the 14C that was extractable from the feces (73 to 75% of the 14C in feces was extractable with methanol). Goat milk samples collected 16 hr after the last dose contained no detectable 14C. Tissue residues of 14C were determined. |
| Databáze: | OpenAIRE |
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