The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis

Autor: Vuillermoz Sylvie, Freynet Olivia, Catinon Mikael, Bonneterre Vincent, Freymond Nathalie, Pison Christophe, Kambouchner Marianne, Pecquet Mathieu, Roux Elisabeth, Cavalin Catherine, Chemarin Cécile, Blanchet Anne-Sophie, Arbib François, Mornex Jean-Francois, Pacheco Yves, Thivolet Francoise, Rosental Paul-andré, Vincent Michel, Valeyre Dominique, Rio Stephane, Bernaudin Jean-Francois, Natalizio Audrey
Přispěvatelé: Hellénisation et romanisation dans le monde antique (HeRMA), Université de Poitiers, Environnement et Prédiction de la Santé des Populations (TIMC-IMAG-EPSP), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Sciences Po (Sciences Po), Centre d'études européennes et de politique comparée (Sciences Po, CNRS) (CEE), Sciences Po (Sciences Po)-Centre National de la Recherche Scientifique (CNRS), Hôpital Saint Joseph, École supérieure du professorat et de l'éducation - Académie de Versailles (ESPE Versailles), Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Université de Bordeaux (UB), Clinique de pneumologie, CHU Grenoble, Service de Pneumologie [Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Centre de Compétence pour les Maladies Pulmonaires Rares, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU), DHU FIRE Centre de compétence des maladies pulmonaires rares, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Département de Pneumologie [HCL, Lyon], Service d’anatomie pathologique, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'histoire de Sciences Po (Sciences Po) (CHSP), European Project: 295817,EC:FP7:ERC,ERC-2011-ADG_20110406,SILICOSIS(2012), Centre d'études européennes et de politique comparée (CEE), Centre d'histoire de Sciences Po (CHSP)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: ERS International Congress 2016 abstracts
ERS International Congress 2016 abstracts, Sep 2016, Londres, United Kingdom. pp.PA397, ⟨10.1183/13993003.congress-2016.PA397⟩
European Respiratory Journal
European Respiratory Journal, 2016, 48 (suppl 60), ⟨10.1183/13993003⟩
European Respiratory Journal, 48(suppl 60 ), .-(2016-11)
European Respiratory Journal, European Respiratory Society, 2016, 48 (suppl 60), ⟨10.1183/13993003⟩
ISSN: 0903-1936
1399-3003
DOI: 10.1183/13993003.congress-2016.PA397⟩
Popis: International audience; Introduction: it has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8).Objectives: in order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts.Methods: The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test.Results: The “dust score” was found significantly higher in patients with sarcoidosis than in HV (p=0,036; Wilcoxon signed-rank test). Moreover we found a significant overrepresentation of people exposed to building activities among the cases. However this remains to be assessed on a larger series.Conclusion: The SQ demonstrated a significantly higher level of exposure to inorganic dusts in patients with sarcoidosis compared to HV. Such preliminary results encourage 1) to study the association between sarcoidosis and inorganic dust exposure and 2) to submit routinely this exposure questionnaire to every patient with a granulomatous disease.
Databáze: OpenAIRE
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