Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata
| Autor: | Jon Clardy, Christine Beemelmanns, Huijuan Guo, Martin Sperfeld, Klaus Dieter Menzel, Maja Rischer, Christiane Weigel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell signaling media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Biochemistry Hydractinia echinata Mass Spectrometry Article Microbiology 03 medical and health sciences RNA Ribosomal 16S Drug Discovery Botany Animals Metamorphosis Molecular Biology Chromatography High Pressure Liquid Phylogeny media_common Larva Biological Products biology Bacteria Organic Chemistry Metamorphosis Biological High-Throughput Nucleotide Sequencing Sequence Analysis DNA biology.organism_classification 030104 developmental biology Hydrozoa Hydroid (zoology) Associated bacteria Molecular Medicine Proteobacteria Developmental biology Gammaproteobacteria |
| Zdroj: | Bioorganicmedicinal chemistry. 25(22) |
| ISSN: | 1464-3391 |
| Popis: | Illumina 16S rRNA gene sequencing was used to profile the associated bacterial community of the marine hydroid Hydractinia echinata, a long-standing model system in developmental biology. 56 associated bacteria were isolated and evaluated for their antimicrobial activity. Three strains were selected for further in-depth chemical analysis leading to the identification of 17 natural products. Several γ-Proteobacteria were found to induce settlement of the motile larvae, but only six isolates induced the metamorphosis to the primary polyp stage within 24 h. Our study paves the way to better understand how bacterial partners contribute to protection, homeostasis and propagation of the hydroid polyp. |
| Databáze: | OpenAIRE |
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