LIPID PROFILE AND ITS RATIO AS SURROGATE MARKER OF INSULIN RESISTANCE IN OBESE PATIENTS
| Autor: | Sneha Thomas, Sudagar Singh R B, Senthil N, J. Damodharan, C. Sujeetha, S. Sujatha |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Evidence Based Medicine and Healthcare, Vol 2, Iss 45, Pp 8190-8195 (2015) |
| ISSN: | 2349-2570 2349-2562 |
| Popis: | BACKGROUND : Insulin resistance plays a significant role in evolution of atherosclerosis and cardiovascular diseases . 1 Early assessment of this resistance will provide sufficient time in preventing this progression. The prevailing method of assessing this resistance i s cumbersome and time consuming. This study is done to assess the relationship between lipid profile (lipoproteins) and insulin resistance which in turn will act as an easy marker of predicting insulin resistance in cl inical setting. OBJECTIVE: The aim of this study is to assess the correlation of lipid profile and its ratio ’ s with insulin resistance and its predictability in identifying insulin resistance. METHODS: This is a cross sectional study of 100 obese patients without diabetes. Obesity was defined by Body mass index (BMI) greater than 30. Fasting blood was obtained for Lipid profile, Insulin and blood glucose. Post prandial blood was taken for blood glucose. HOMA - IR model was chosen for calculating insulin resistance. Results obtained were analysed by student ’ s t - test and Pearson ’ s correlation done for the same. RESULTS AND OBSERVAT ION: The data on analysis revealed triglycerides, triglyceride/hdl - c ratio, total cholesterol/hdl - c ratio and serum fasting insulin level were significantly higher in homa - ir>2.5 group with statistical significance, comparing with other group. CONCLUSION: Tri glycerides, triglyceride/hdl - c and total cholesterol/hdl - c ratios can be used as a simple surrogate marker of insulin resistance in clinical setting in obese non diabetic individuals. |
| Databáze: | OpenAIRE |
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