Tracheoesophageal anastomosis, continent gastrostomy and oesophagostomy-a new experimental model in minipiglets

Autor: E. Unsü, L. Ruprecht, Klaus Schaarschmidt, G.H. Willital, K. W. Paschertz, U. Stratmann
Rok vydání: 1995
Předmět:
Zdroj: Laboratory Animals. 29:411-419
ISSN: 1758-1117
0023-6772
DOI: 10.1258/002367795780740131
Popis: Tracheoesophageal fistulae endanger newborn children by aspiration pneumonia. An animal model of this dangerous malformation was thought to be impossible until now. By tracheoesophageal anastomosis, occlusion of the oesophagogastral junction, proximal cervical oesophagostomy and continent gastrostomy in 25 minipiglets a reliable model of tracheoesophageal fistula has been developed. After establishing the model in a pilot study the mortality following the establishment of this procedure was 5.6% and the minipiglets survived in excellent condition for 2-10 week periods under complete alimentary restriction and gastrostomy feeding. Therefore the method seems to be suitable for long-term investigations on major oesophagotracheal surgery.
Databáze: OpenAIRE