The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma
| Autor: | Mackay, T.M., Smits, F.J., Roos, D., Bonsing, B.A., Bosscha, K., Busch, O.R., Creemers, G.J., Dam, R.M. van, Eijck, C.H.J. van, Gerhards, M.F., Groot, J.W.B. de, Koerkamp, B.G., Mohammad, N.H., Harst, E. van der, Hingh, I.H.J.T. de, Homs, M.Y.V., Kazemier, G., Liem, M.S.L., Meijer, V.E. de, Molenaar, I.Q., Nieuwenhuijs, V.B., Santvoort, H.C. van, Schelling, G.P. van der, Stommel, M.W.J., Tije, A.J. ten, Vos-Geelen, J. de, Wit, F., Wilmink, J.W., Laarhoven, H.W.M. van, Besselink, M.G., Dutch Pancreatic Canc Grp |
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| Přispěvatelé: | Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, Oncology, CCA - Cancer Treatment and quality of life, Medical Oncology, Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
SURGERY medicine.medical_treatment INTERNATIONAL STUDY-GROUP 030230 surgery SURGICAL COMPLICATIONS Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine Risk Factors Odds Ratio Hospital Mortality POSTOPERATIVE COMPLICATIONS Netherlands Gastroenterology Age Factors Middle Aged Pancreaticoduodenectomy OPEN-LABEL CANCER Pancreatic fistula Chemotherapy Adjuvant 030220 oncology & carcinogenesis PANCREATICODUODENECTOMY Female medicine.drug Carcinoma Pancreatic Ductal medicine.medical_specialty Hospitals Low-Volume 03 medical and health sciences Pancreatectomy Pancreatic cancer medicine Journal Article Humans Aged Retrospective Studies Chemotherapy Performance status Hepatology business.industry MORTALITY Postoperative complication Odds ratio medicine.disease Gemcitabine Surgery Pancreatic Neoplasms Logistic Models DEFINITION GEMCITABINE Neoplasm Grading business |
| Zdroj: | HPB: The official journal of the International Hepato Pancreato Biliary Association, 22(2), 233-240. John Wiley and Sons Inc. Hpb, 22, 2, pp. 233-240 International Hepato-Pancreato Biliary Association., 22(2), 233. John Wiley and Sons Inc. HPB, 22(2), 233-240. ELSEVIER SCI LTD HPB, 22(2), 233-240. John Wiley and Sons Inc. HPB, 22(2), 233-240. John Wiley & Sons Inc. Hpb, 22(2), 233-240. ELSEVIER SCI LTD Mackay, T M, Smits, F J, Roos, D, Bonsing, B A, Bosscha, K, Busch, O R, Creemers, G-J, van Dam, R M, van Eijck, C H J, Gerhards, M F, de Groot, J W B, Groot Koerkamp, B, Haj Mohammad, N, van der Harst, E, de Hingh, I H J T, Homs, M Y V, Kazemier, G, Liem, M S L, de Meijer, V E, Molenaar, I Q, Nieuwenhuijs, V B, van Santvoort, H C, van der Schelling, G P, Stommel, M W J, ten Tije, A J, de Vos-Geelen, J, Wit, F, Wilmink, J W, van Laarhoven, H W M, Besselink, M G & Dutch Pancreatic Cancer Group 2020, ' The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: a nationwide analysis ', HPB, vol. 22, no. 2, pp. 233-240 . https://doi.org/10.1016/j.hpb.2019.06.019 Hpb, 22, 233-240 |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2019.06.019 |
| Popis: | Contains fulltext : 226028.pdf (Publisher’s version ) (Closed access) BACKGROUND: The relation between type of postoperative complication and not receiving chemotherapy after resection of pancreatic ductal adenocarcinoma (PDAC) is unclear. The aim was to investigate which patient factors and postoperative complications were associated with not receiving adjuvant chemotherapy. METHODS: Patients who underwent resection (2014-2017) for PDAC were identified from the nationwide mandatory Dutch Pancreatic Cancer Audit. The association between patient-, tumor-, center-, treatment characteristics, and the risk of not receiving adjuvant chemotherapy was analyzed with multivariable logistic regression. RESULTS: Overall, of 1306 patients, 24% (n = 312) developed postoperative Clavien Dindo ≥3 complications. In-hospital mortality was 3.5% (n = 46). Some 433 patients (33%) did not receive adjuvant chemotherapy. Independent predictors (all p |
| Databáze: | OpenAIRE |
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