Molecularly-targeted therapy for the oral cancer stem cells
| Autor: | Hiroki Yasui, Yuichi Ohnishi, Masami Nozaki, Masahiro Nakajima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Molecularly-targeted therapy medicine.medical_treatment Cetuximab Review Article Lapatinib Metastasis Targeted therapy 03 medical and health sciences 0302 clinical medicine Growth factor receptor Cancer stem cell medicine Epidermal growth factor receptor skin and connective tissue diseases General Dentistry neoplasms biology business.industry Cancer stem cells medicine.disease Metastatic breast cancer Sphere formation lcsh:RK1-715 030104 developmental biology Oral squamous cell carcinoma lcsh:Dentistry 030220 oncology & carcinogenesis Cancer research biology.protein business medicine.drug |
| Zdroj: | The Japanese Dental Science Review Japanese Dental Science Review, Vol 54, Iss 2, Pp 88-103 (2018) |
| ISSN: | 2213-6851 1882-7616 |
| Popis: | Summary: Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer. In this review, cetuximab and lapatinib-resistant oral squamous cell carcinoma (OSCC) cells proliferation and migration signal transduction passway is discussed by introducing our research. Keywords: Cancer stem cells, Cetuximab, Lapatinib, Epidermal growth factor receptor, Oral squamous cell carcinoma, Molecularly-targeted therapy, Sphere formation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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