654. Targeting Adenoviral Vectors for Use in Breast Cancer Gene Therapy

Autor:	Mabrouk M. Elgadi, Leonard I. Wiebe, Mary M. Hitt, Chang-Xin Shi, Alan D. DeSilva, Gianluca Bossi
Rok vydání:	2006
Předmět:	Pharmacology Genetic enhancement Cell Promoter Gene delivery Biology medicine.disease Viral vector medicine.anatomical_structure Breast cancer Drug Discovery Immunology Genetics medicine Cancer research Molecular Medicine Receptor Molecular Biology Gene
Zdroj:	Molecular Therapy. 13:S252
ISSN:	1525-0016
DOI:	10.1016/j.ymthe.2006.08.730
Popis:	The results of many cancer gene therapy clinical trials to date suggest that improvements must be made to increase gene delivery, expression levels, and/or potency of the genes in order to induce tumour regression. However, increasing any of these parameters will require additional safeguards to protect surrounding normal cells. Our goal is to develop adenoviral vector systems that target tumour cells transcriptionally (using various tumour- and tissue- specific promoters) as well as transductionally (by modifying the viral fiber protein to enhance binding to receptors on the tumour cell surface).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab2e6792e9a8fa5bc81369662b76784 https://doi.org/10.1016/j.ymthe.2006.08.730 Zobrazit plný text záznamu