The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis
| Autor: | Jan J. Stepan, Dana Michalska, Vit Zikan, Ales Kubena, Ivan Raška, Maria Luchavova |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Osteoporosis Bone remodeling Endocrinology N-terminal telopeptide Bone Density Teriparatide Internal medicine Humans Medicine Circadian rhythm Osteoporosis Postmenopausal Aged Morning Aged 80 and over Calcium metabolism Bone Density Conservation Agents business.industry General Medicine Middle Aged Circasemidian rhythm medicine.disease Circadian Rhythm Female business medicine.drug |
| Zdroj: | European Journal of Endocrinology. 164:643-648 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-10-1108 |
| Popis: | BackgroundWe hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover.MethodsThe concentration of serum C-terminal telopeptide of collagen type I (βCTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3 h over a 24 h period in 14 postmenopausal osteoporotic women (aged 72.4±9.3 years) treated with 20 μg TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.ResultsGLM-RM for both related groups showed a significant influence of time of day on all measured variables except P1NP. The analysis for each group separately provided a powerful model for βCTX (Pη2=0.496), serum iCa (Pη2=0.423), plasma PTH (Pη2=0.283), and serum PINP (Pη2=0.248). While the evening TPTD treatment showed a marked circadian rhythm for serum βCTX, the morning TPTD treatment rather suggested circasemidian rhythm. The P1NP rhythm followed a much smaller amplitude of the rhythm than βCTX. Changes in serum iCa were positively related to changes in serum βCTX (PPConclusionTiming of TPTD administration may significantly change the 24 h variation in bone turnover markers as well as calcium-parathyroid axis in postmenopausal osteoporotic women. |
| Databáze: | OpenAIRE |
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