Current practice of Gleason grading among genitourinary pathologists
| Autor: | Jonathan I. Epstein, Lars Egevad, William C. Allsbrook |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology medicine.medical_treatment Gleason grading urologic and male genital diseases Pathology and Forensic Medicine Prostate cancer Surveys and Questionnaires Pathology Humans Medicine Grading (tumors) Aged Transurethral resection of the prostate Gynecology business.industry Genitourinary system General surgery Biopsy Needle Prostatic Neoplasms Reproducibility of Results Professional Practice Anatomical pathology Middle Aged medicine.disease surgical procedures operative Current practice Needle biopsy business |
| Zdroj: | Human Pathology. 36:5-9 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2004.10.001 |
| Popis: | There is consensus that the Gleason system should be used for grading of prostate cancer. However, a number of controversial issues remain as regards how this grading is applied. A questionnaire was sent to 91 genitourinary pathologists in countries around the world with the purpose to survey current practice of Gleason grading. The response rate was 74%, including 43 North American pathologists and 24 from other continents. Of all participants, only 13% and 36%, respectively, ever diagnosed a Gleason score (GS) of 2 to 3 or 4 on needle biopsies (NBX), and 88% of those who did so assigned a GS 4 to1% of cancers. Cribriform Gleason pattern (GP) 3 was acknowledged by 88% but a majority of them would classifyor =20% of cribriform patterns as GP 3. One third only accepted cribriform or fusion patterns as GP 4, but two thirds also included incomplete or poorly defined glands. For GP 5 to be identified on NBX, 83% required clusters of individual cells, strands, or nests seen at less than x40 lens magnification. Only 26% defined GS on NBX as primary + tertiary GP, and a majority would mention a tertiary pattern separately. For NBX, global or highest GS was reported by 40% and 10%, respectively, whereas 46% only gave a separate GS for each individual NBX core. In conclusion, there is a need to standardize practical application of Gleason grading both in terms of interpretation of patterns as well as how grading is reported. Our survey data provide information to general pathologists about the most common grading practices among genitourinary pathologists. |
| Databáze: | OpenAIRE |
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