Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
| Autor: | Vladimir I. Novoselov, S. B. Parfenyuk, Mars G. Sharapov, Olga V. Glushkova, Sergey M Lunin, A. E. Gordeeva, Maxim O. Khrenov, T. V. Novoselova, Elena G Novoselova, E. E. Fesenko |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Thymic Factor Circulating MAP Kinase Kinase 4 Anti-Inflammatory Agents Antioxidants chemistry.chemical_compound Mice 0302 clinical medicine Blood plasma Drug Discovery Immunology and Allergy Original Research Article NF-kappa B signaling streptozotocin-induced diabetes medicine.drug Signal Transduction medicine.medical_specialty Immunology 030209 endocrinology & metabolism Diabetes Mellitus Experimental 03 medical and health sciences Thymulin Interferon-gamma Immune system Diabetes mellitus Internal medicine medicine Diabetes Mellitus Animals peroxiredoxin 6 Pharmacology Type 1 diabetes business.industry SARS-CoV-2 Tumor Necrosis Factor-alpha Interleukins COVID-19 medicine.disease Streptozotocin NFKB1 cytokines COVID-19 Drug Treatment 030104 developmental biology Endocrinology chemistry Cytokine storm business Peroxiredoxin VI thymulin |
| Zdroj: | International Journal of Immunopathology and Pharmacology |
| ISSN: | 2058-7384 |
| Popis: | Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of prolonged treatment with PRDX6 or thymic peptide thymulin on diabetes development were evaluated. We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-α, interleukin-5 and 17, and interferon-γ), activity of NF-κB and JNK pathways, and Hsp90α expression in immune cells. Both thymulin and PRDX6 reduced the physiological impairments in diabetic mice at various levels. Thymulin and PRDX6 provide beneficial effects in the model of diabetes via very different mechanisms. Taken together, the results of our study indicated that the thymic peptide and the antioxidant enzyme have anti-inflammatory functions. As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients. |
| Databáze: | OpenAIRE |
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