Risk factors detection in chronic thromboembolic pulmonary hypertension, a tool for risk quantification?
| Autor: | J. Vesely, Anna Remková, Iveta Simkova, Tatiana Valkovicova, Monika Kaldararova, M. Bohacekova |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Economics and Econometrics medicine.medical_specialty Deep vein medicine.medical_treatment Hypertension Pulmonary Splenectomy 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Risk Factors Internal medicine Epidemiology Materials Chemistry Media Technology medicine Prevalence Humans 030212 general & internal medicine Mean platelet volume Lung Aged Venous Thrombosis Hematology biology business.industry Platelet Count Anticoagulants Fibrinogen Forestry Middle Aged medicine.disease Thrombosis Pulmonary embolism medicine.anatomical_structure Chronic Disease biology.protein Cardiology Female business Pulmonary Embolism |
| Zdroj: | Bratislavske lekarske listy. 117(10) |
| ISSN: | 0006-9248 |
| Popis: | BACKGROUND Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by chronic thromboembolic obstruction in the pulmonary bed. The definitive pathogenesis remains incompletely explained, although multiple risk factors of CTEPH have been identified. The purpose of the study was to evaluate the risk profile of patients with CTEPH and the representativeness of risk factors, identify possible new CTEPH risk factors and specify the epidemiology of CTEPH in our country. METHODS In 81 patients with CTEPH, well known risk factors were analyzed, and a detailed analysis of selected hematological parameters was investigated at a specialized hematology laboratory. RESULTS CTEPH risk factors were identified as follows: pulmonary embolism (PE), deep vein thrombosis (DVT), thyreopathy, blood type other than "0", inflammatory bowel disease, malignancy, splenectomy, pacemaker. When compared to healthy controls, the following was observed: a significant decrease in platelet count, higher mean platelet volume, higher spontaneous platelet aggregation, increase in von Willebrand factor and fibrinogen. The median of risk factors representativeness was 3 (PE, DVT, blood type other than "0"). The prevalence of CTEPH in adult population in our country is estimated to be 1.8 per 100,000 inhabitants. CONCLUSION In the study we confirmed multiple established risk factors of CTEPH, set their representativeness, identified some platelet abnormalities which could be a potential new risk marker and specified the prevalence of CTEPH (Tab. 5, Ref. 35). |
| Databáze: | OpenAIRE |
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