Plasma membrane integrity: implications for health and disease
| Autor: | John H. Brumell, Dustin A. Ammendolia, William M. Bement |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell type
Pore formation Physiology QH301-705.5 Lipid peroxidation Cellular homeostasis Membrane damage Membrane repair Review Plant Science Disease Vesicle trafficking Biology Disease pathogenesis General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Structural Biology Homeostasis Biology (General) Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Cell Membrane Cell Biology Tissue injury Cell biology Membrane Membrane integrity General Agricultural and Biological Sciences 030217 neurology & neurosurgery Developmental Biology Biotechnology Plasma membrane |
| Zdroj: | BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021) BMC Biology |
| ISSN: | 1741-7007 |
| Popis: | Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity. Here, we assess plasma membrane damage and repair from a whole-body perspective. We highlight the role of tissue-specific stressors in health and disease and examine membrane repair pathways across diverse cell types. Furthermore, we outline the impact of genetic and environmental factors on plasma membrane integrity and how these contribute to disease pathogenesis in different tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |