Recent Developments on the Synthesis and Biological Activities of Fused Pyrimidinone Derivatives
| Autor: | Paul Awolade, Pule Seboletswe, Parvesh Singh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Molecular Structure 010405 organic chemistry Organic Chemistry Anti-Inflammatory Agents Antineoplastic Agents Computational biology Pyrimidinones 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Anti-Infective Agents Drug Development Research community Drug Discovery Molecular Medicine Humans Hypoglycemic Agents General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | ChemMedChem. 16(13) |
| ISSN: | 1860-7187 |
| Popis: | Heterocyclic compounds constitute a unique class of organic compounds endowed with a wide range of synthetic and pharmaceutical applications. Pyrimidinones and their fused analogues have received focused attention in this regard, partly due to their mimicry of nucleobases which consequently forges their interesting medicinal properties. Over the years, the medicinal chemistry research community has experienced an upsurge in articles describing the exploration of these scaffolds to develop effective therapeutic agents. Several biological activities, including antimicrobial, antiviral, anticancer, antidiabetic, anti-inflammatory, anticonvulsive, and antihistaminic, have been well documented. This minireview presents a compendium of recent developments (2017-2020) focused on the synthesis and biological activities of fused pyrimidinones. The goal is to update medicinal chemists on the therapeutic relevance of fused pyrimidinones and the molecular architecture of clinic-worthy drug candidates. A brief account of the structure-activity relationships (SAR) revealed from different biological assays is also discussed. |
| Databáze: | OpenAIRE |
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