Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells
| Autor: | Ying V. Zhang, Tudorita Tumbar, David J. McDermitt, Nichita Ciapurin, Janice Cheong |
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| Rok vydání: | 2009 |
| Předmět: |
Time Factors
Cell division Cellular differentiation Antigens CD34 Biology Integrin alpha6 Models Biological Article 03 medical and health sciences Mice 0302 clinical medicine Genetics medicine Animals Homeostasis Cell Lineage Progenitor cell Stem Cell Niche 030304 developmental biology Progenitor Cell Proliferation 0303 health sciences Gene Expression Profiling Stem Cells Cell Differentiation Cell Biology Anatomy Hair follicle STEMCELL Cell biology medicine.anatomical_structure Stem cell division Molecular Medicine Stem cell Hair Follicle 030217 neurology & neurosurgery Cell Division Adult stem cell |
| Zdroj: | Cell stem cell. 5(3) |
| ISSN: | 1875-9777 |
| Popis: | SummaryIn homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell committed to differentiate. This model is based largely on in vivo invertebrate or in vitro mammal studies. Here, we examine the dynamic behavior of adult hair follicle stem cells in their normal setting by employing mice with repressible H2B-GFP expression to track cell divisions and Cre-inducible mice to perform long-term single-cell lineage tracing. We provide direct evidence for the infrequent stem cell division model in intact tissue. Moreover, we find that differentiation of progenitor cells occurs at different times and tissue locations than self-renewal of stem cells. Distinct fates of differentiation or self-renewal are assigned to individual cells in a temporal-spatial manner. We propose that large clusters of tissue stem cells behave as populations whose maintenance involves unidirectional daughter-cell-fate decisions. |
| Databáze: | OpenAIRE |
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