Hyperhomocysteinemia and low vitamin B12 are associated with the risk of early pregnancy loss: A clinical study and meta-analyses
| Autor: | Singh Rajender, Priyanka Verma, Kiran Singh, Renu Bala, Nisha Rani Agrawal, Namrata Yadav, Rachna Verma, Vertika Singh |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Hyperhomocysteinemia Homocysteine Endocrinology Diabetes and Metabolism Early Pregnancy Loss Nutritional Status Physiology 030209 endocrinology & metabolism Folic Acid Deficiency Clinical study Young Adult 03 medical and health sciences chemistry.chemical_compound Folic Acid 0302 clinical medicine Endocrinology Meta-Analysis as Topic Pregnancy Risk Factors Odds Ratio medicine Humans Vitamin B12 030109 nutrition & dietetics Nutrition and Dietetics business.industry Vitamin B 12 Deficiency Maternal Nutritional Physiological Phenomena medicine.disease Abortion Spontaneous Pregnancy Complications Vitamin B 12 First trimester Folic acid chemistry Case-Control Studies Female business |
| Zdroj: | Nutrition Research. 91:57-66 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2021.05.002 |
| Popis: | One-carbon metabolism is crucial for the maintenance of healthy pregnancy and alterations in this pathway have been associated with various pregnancy-related complications. Therefore, the present study was conducted to test the hypothesis that the altered folic acid, vitamin B12 and homocysteine levels are associated with the risk of early pregnancy loss (EPL). Plasma folic acid, vitamin B12 and homocysteine levels were analyzed in 83 females with EPL and 70 healthy pregnant females in their first trimester. Further, meta-analyses of folic acid, vitamin B12 and homocysteine were also performed involving various eligible studies. Results from our case-control study and meta-analysis showed that folic acid deficiency is not associated with the risk of EPL. On the other hand, low vitamin B12 and hyperhomocysteinemia were individually found to be significant risk factors for EPL in the present study (P.01, P.05, respectively) and meta-analysis as well (P.001, P.05, respectively). Vitamin B12 deficiency in combination with hyperhomocysteinemia was a more serious risk factor for EPL (Odds Ratio = 4.98, P = 0.002). Therefore, we conclude that vitamin B12 deficiency and elevated homocysteine levels are independent risk factors for EPL, and of higher risk when combined. The assessment of vitamin B12 and homocysteine levels may serve as a good screening marker for EPL risk. |
| Databáze: | OpenAIRE |
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