Aortic root blood flow increases after pancuronium in neonates with hyaline membrane disease
| Autor: | Christine E. Blackwell, Dennis T. Costakos, Peter A. M. Auld, Alex E. Wiercinski, Carolyn Eisen, Kimon Violaris, Alfred N. Krauss |
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| Rok vydání: | 1991 |
| Předmět: |
Hyaline Membrane Disease
Hemodynamics Blood Pressure Doppler echocardiography Critical Care and Intensive Care Medicine Heart Rate medicine.artery medicine Humans Pancuronium Prospective Studies Aorta Hyaline medicine.diagnostic_test business.industry Pancuronium bromide Infant Newborn Blood flow Stroke volume Carbon Dioxide Oxygen Anesthesia Circulatory system Vascular Resistance business Blood Flow Velocity medicine.drug |
| Zdroj: | Critical Care Medicine. 19:187-190 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/00003246-199102000-00013 |
| Popis: | Objective To determine the effects of muscle paralysis on aortic root blood flow in preterm infants with hyaline membrane disease. Design Each patient served as his/her own control in a prospectively controlled trial. Setting Neonatal ICU in a university hospital. Patients Ten ventilator-dependent preterm infants weighing 800 to 2820 g, 0 to 8 days of age, with hyaline membrane disease and seven control patients. Interventions Noninvasive measurement of aortic root blood flow by Doppler echocardiography 30 min before and 60 min after respiratory paralysis with 0.1 to 0.5 mg/kg of iv pancuronium, or following ventilator changes in control subjects. Results Mean aortic root blood flow increased significantly (p less than .001), from 212 to 276 mL/min.kg, accompanied by significant increases in stroke volume and heart rate. Conclusions Pancuronium bromide may have a direct beneficial effect on the circulation of preterm infants with hyaline membrane disease. |
| Databáze: | OpenAIRE |
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