COVID-19 Morbidity and Severity in Patients With Age-Related Macular Degeneration: A Korean Nationwide Cohort Study

Autor: Seung Won Lee, Dritan Agalliu, Jee Myung Yang, Jooyoung Lee, Sung Yong Moon, Dong Keon Yon
Rok vydání: 2021
Předmět:
medicine.medical_specialty
aOR
adjusted odds ratio
exudative age-related macular degeneration
Population
severity
ACE 2
angiotensin-converting enzyme 2
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Article
susceptibility
Cohort Studies
03 medical and health sciences
Macular Degeneration
0302 clinical medicine
COVID-19 Testing
Internal medicine
medicine
Humans
SMDs
standardized mean differences
AMD
age-related macular degeneration
education
age-related macular degeneration
COVID-19
coronavirus disease
030304 developmental biology
0303 health sciences
education.field_of_study
ICD-10
International Classification of Disease 10th revision
business.industry
SARS-CoV-2
COVID-19
RAS
renin-angiotensin system
Odds ratio
Macular degeneration
medicine.disease
Confidence interval
CI
confidence interval
Ophthalmology
COPD
chronic obstructive pulmonary disease
Cohort
Propensity score matching
030221 ophthalmology & optometry
Population study
Morbidity
SD
standard deviation
business
Cohort study
Zdroj: American Journal of Ophthalmology
ISSN: 1879-1891
Popis: Objective To determine the potential association of age-related macular degeneration (AMD), a representative chronic age-related degenerative disease of the retina associated with inflammation and aging, with susceptibility to SARS-CoV-2 infection and severe COVID-19 outcomes. Design Nationwide cohort study with propensity-score matching. Setting Population-based nationwide cohort in Korea. Study population Data were obtained from the Health Insurance Review & Assessment Service of Korea, including all patients older than 40 years who underwent SARS-CoV-2 testing in South Korea between January 1, 2020, and May 15, 2020 (excluding self-referral). Main outcome measures SARS-CoV-2 test positivity was the primary outcome and severe clinical outcome of COVID-19 was the secondary outcome. Results The unmatched cohort consisted of 135,435 patients who were tested for SARS-CoV-2; 4531 (3.3%) tested positive for SARS-CoV-2; 5493 (4.1%) patients had AMD. After propensity score matching, exudative AMD was associated with an increased likelihood of susceptibility to SARS-CoV-2 infection (adjusted odds ratio [aOR], 1.50; 95% confidence interval [CI], 1.03-2.25), and a considerably greater risk of severe clinical outcomes of COVID-19 (aOR, 2.26; 95% CI, 1.02 to 5.26), but not any AMD and non-exudative AMD. Conclusions In a Korean nationwide cohort, our data suggest that clinicians should be aware of the greater risk of susceptibility to severe clinical outcomes of COVID-19 in patients with exudative AMD. Our findings provide an improved understanding of the relationship between the pathogenesis of COVID-19 and chronic neurological disorders.
Databáze: OpenAIRE
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