Modeling and simulation of continuous powder blending applied to a continuous direct compression process

Autor:	Seongkyu Yoon, Shaun C. Galbraith, Huolong Liu, Bumjoon Cha, Zhuangrong Huang, Seo-Young Park
Rok vydání:	2018
Předmět:	Compressive Strength Computer science business.industry Chemistry Pharmaceutical Process (computing) Pharmaceutical Science 02 engineering and technology General Medicine Continuous manufacturing 021001 nanoscience & nanotechnology Residence time distribution Modeling and simulation 020401 chemical engineering Models Chemical Compression (functional analysis) Key (cryptography) Computer Simulation 0204 chemical engineering Powders 0210 nano-technology Process engineering business ComputingMethodologies_COMPUTERGRAPHICS
Zdroj:	Pharmaceutical development and technology. 23(10)
ISSN:	1097-9867
Popis:	Continuous manufacturing techniques are increasingly being adopted in the pharmaceutical industry and powder blending is a key operation for solid-dosage tablets. A modeling methodology involving axial and radial tanks-in-series flowsheet models is developed to describe the residence time distribution (RTD) and blend uniformity of a commercial powder blending system. Process data for a six-component formulation processed in a continuous direct compression line (GEA Pharma Systems) is used to test the methodology. Impulse tests were used to generate experimental RTDs which are used along with parameter estimation to determine the number of axial tanks in the flowsheet. The weighted residual from the parameter estimation was less than the χ
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3c33938c64de386ed7c347d997b791 https://pubmed.ncbi.nlm.nih.gov/29304722 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.