Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: Preliminary correlations with local control and overall survival
| Autor: | J.P. Pignon, J. Gazeau, Theodore Girinsky, Bernard Dubray, Jean-Marc Cosset, R. Lubin, Bernard Fertil, N. Chavaudra, G. Socie |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
medicine.medical_specialty Urology Uterine Cervical Neoplasms Alpha (ethology) In Vitro Techniques Radiation Tolerance Predictive Value of Tests Median follow-up medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Radiosensitivity Survival rate Retrospective Studies Radiation Epithelioma business.industry Head and neck cancer medicine.disease In vitro Surgery Survival Rate Treatment Outcome Oncology Head and Neck Neoplasms Carcinoma Squamous Cell Female France Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 25:3-7 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(93)90137-k |
| Popis: | Purpose : To determine whether in vitro radiosensitivity parameters are predictive of treatment outcome. Methods and Materials : Biopsies were obtained from patients with head and neck cancers (57) and cervical carcinomas (20) and in vitro radiosensitivity parameters were obtained using the CAM plate assay. Results : In most cases (75%) patients were treated with radiation alone. The median follow up was 461 days. When the whole group of head and neck cancers and cervical carcinomas was considered, patients with a SFZ value below 0.36 had a higher 2-year local control rate (93% versus 68%) and a higher 2-year survival rate (71% vs. 62%) than those with SFZ values above that threshold, but differences were not significant. These trends persisted when head and neck cancers were considered alone with a higher local control rate (86% vs. 67%) and a higher survival rate (75% vs. 52.5%) obtained for patients with a SFZ value below 0.36. When the alpha value was evaluated for the whole group of patients a significantly higher local control rate (80.5% vs. 40.5%) and overall survival rate (71% versus 37.5%) at 2 years were obtained for patients with alpha values above 0.07 Gy−1 When only the group of head and neck cancers was considered, local control rate was significantly higher (79% vs. 33%) but overall survival rate (65.5% vs. 33%) was not significantly higher for alpha values above 0.07 Gy−1. Conclusion : These results are encouraging but need to be confirmed with a larger number of patients with a longer follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|