Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study

Autor:	Sandeep Jain, Dhara Shah, Kyung-No Son, Sushma Kalmodia, Bayasgalan Surenkhuu, Marwan Ali, Dingcai Cao, Bao-Shiang Lee, Arun Balasubramaniam, Vinay K. Aakalu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Adult Male medicine.medical_specialty Patient characteristics Down-Regulation lcsh:Medicine Histatins Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Preliminary report Internal medicine Medicine Humans lcsh:Science Multidisciplinary business.industry Extramural lcsh:R Case-control study HISTATIN 1 Diagnostic markers Translational research Middle Aged Normal group 030104 developmental biology ROC Curve Case-Control Studies Tears Linear Models Dry Eye Syndromes Female lcsh:Q business 030217 neurology & neurosurgery Biomarkers
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-019-46623-9
Popis:	The aims of this study were to determine if histatin-1 (H1) is present in normal human tears and whether tear levels of H1 varied between normal patients and those with aqueous deficient dry eye disease (ADDE). Patient samples were obtained from 11 normal patients and 11 severe ADDE patients. Relevant patient characteristics, including age, sex, and dry eye disease (DED) diagnostic parameters were collected. Multiple qualitative and quantitative methods were used to compare the concentration of H1 between patient groups. Mixed linear modeling was used to compare H1 levels between groups, and diagnostic performance was assessed using the receiver-operator-characteristic (ROC). ADDE patients had significantly lower H1 concentrations (85.9 ± 63.7 ng/ml) than the normal group (891.6 ± 196.5 ng/ml) (p 13) and Schirmer I (without anesthesia) (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba20d133ab1b1772de07f3d0e76af21f http://link.springer.com/article/10.1038/s41598-019-46623-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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