Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease
| Autor: | Tsutomu Chiba, Tomohiro Watanabe, Norimitsu Uza, Chikage Zaima, Hiroshi Ida, Naoshi Nishida, Shinsuke Tada, Reiko Akitake |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Necrosis Cholangitis Sclerosing Stimulation Biology Ligands Peripheral blood mononuclear cell Autoimmune Diseases Th2 Cells parasitic diseases medicine Humans Receptor Cells Cultured Aged Submandibular lymph nodes Toll-like receptor Toll-Like Receptors Gastroenterology medicine.disease medicine.anatomical_structure Pancreatitis Immunoglobulin G Immunology medicine.symptom Pancreas Infiltration (medical) |
| Zdroj: | Gut. 59(4) |
| ISSN: | 1468-3288 |
| Popis: | We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor alpha and interferon gamma by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease. |
| Databáze: | OpenAIRE |
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