Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment: An fMRI study
| Autor: | Hiroshi Yamashita, Hikaru Doi, Takao Yamasaki, Naomi Takamiya, Tsuyoshi Torii, Naoki Matsuoka, Yumiko Kaseda, Hiroshi Chatani, Shozo Tobimatsu, Tomohiko Ohshita, Yasuyo Mimori, Saeko Inamizu, Hitoka Doi, Toshihiko Aso, Tetsuya Takahashi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male media_common.quotation_subject Motion Perception Posterior parietal cortex Stimulation Stimulus (physiology) 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Perception Medicine Humans Cognitive Dysfunction Visual Pathways Motion perception media_common Aged Visual Cortex Resting state fMRI medicine.diagnostic_test business.industry General Neuroscience Magnetic Resonance Imaging 030104 developmental biology Visual cortex medicine.anatomical_structure Early Diagnosis Disease Progression Female business Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Neuroscience letters. 711 |
| ISSN: | 1872-7972 |
| Popis: | Motion perceptual deficits are common in Alzheimer's disease (AD). Although the posterior parietal cortex is thought to play a critical role in these deficits, it is currently unclear whether the primary visual cortex (V1) contributes to these deficits in AD. To elucidate this issue, we investigated the net activity or connectivity within V1 in 17 amnestic mild cognitive impairment (aMCI) patients, 17 AD patients and 17 normal controls (NC) using functional magnetic resonance imaging (fMRI). fMRI was recorded under two conditions: visual motion stimulation and resting-state. The net activity or connectivity within V1 extracted by independent component analysis (ICA) was significantly increased during visual motion stimuli compared with that of the resting-state condition in NC, but not in aMCI or AD patients. These findings suggest the alteration of the net activity or connectivity within V1, which may contribute to the previously reported motion perceptual deficits in aMCI and AD. Therefore, the decreased net V1 activity measured as the strength of the ICA component may provide a new disease biomarker for early detection of AD. |
| Databáze: | OpenAIRE |
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